Cinobufagin Induces Cell Cycle Arrest at the G2/M Phase and Promotes Apoptosis in Malignant Melanoma Cells

Emerging evidence has shown that cinobufagin, as an active ingredient of Venenum Bufonis, inhibits tumor development. The aim of this study was to investigate the inhibitory effects of cinobufagin on A375 human malignant melanoma cells. MTT and colony formation assays showed that cinobufagin signifi...

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Principais autores:	Zhaohai Pan, Xin Zhang, Pengfei Yu, Xiaoyu Chen, Peng Lu, Minjing Li, Xiaona Liu, Zhipeng Li, Fei Wei, Kejun Wang, Qiusheng Zheng, Defang Li
格式:	Artigo
语言:	Inglês
出版:	Frontiers Media S.A. 2019-09-01
丛编:	Frontiers in Oncology
主题:	cinobufagin melanoma A375 cell mitochondria-mediated apoptosis cell cycle arrest G2/M phase
在线阅读:	https://www.frontiersin.org/article/10.3389/fonc.2019.00853/full
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