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Identification of transcription factor binding sites using ATAC-seq

Abstract Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly understood for ATAC-seq. We propose th...

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Hauptverfasser: Zhijian Li, Marcel H. Schulz, Thomas Look, Matthias Begemann, Martin Zenke, Ivan G. Costa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2019-02-01
Schriftenreihe:Genome Biology
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Online-Zugang:http://link.springer.com/article/10.1186/s13059-019-1642-2
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