The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro

The intrinsically disordered 18.5 kDa classic isoform of MBP (myelin basic protein) interacts with Fyn kinase during oligodendrocyte development and myelination. It does so primarily via a central proline-rich SH3 (Src homology 3) ligand (T92–R104, murine 18.5 kDa MBP sequence numbering) that is par...

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Detalhes bibliográficos

Principais autores:	Miguel De Avila, Kenrick A. Vassall, Graham S. T. Smith, Vladimir V. Bamm, George Harauz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Portland Press 2014-12-01
coleção:	Bioscience Reports
Assuntos:	amphipathic α-helix intrinsically-disordered proteins isothermal titration calorimetry (ITC) myelin basic protein NMR spectroscopy oligodendrocyte poly-proline type II (PPII) SH3-domain
Acesso em linha:	http://www.bioscirep.org/bsr/034/e157/bsr034e157.htm
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