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Aberrant pathways in the late stages of cholesterol biosynthesis in the rat: origin and metabolic fate of unsaturated sterols relevant to the Smith-Lemli-Opitz syndrome

Minor aberrant pathways of cholesterol biosynthesis normally produce only trace levels of abnormal sterol metabolites but may assume major importance when an essential biosynthetic step is blocked. Cholesta-5,8-dien-3β-ol, its Δ5,7 isomer, and other noncholesterol sterols accumulate in subjects with...

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Detalhes bibliográficos
Principais autores: Benfang Ruan, James Tsai, William K. Wilson, George J. Schroepfer, Jr.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2000-11-01
Colecção:Journal of Lipid Research
Assuntos:
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520319702
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