Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the motor neuron diseases: amyotrophic lateral sclerosis (ALS) a...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Archana Prasad, Vidhya Bharathi, Vishwanath Sivalingam, Amandeep Girdhar, Basant K. Patel
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2019-02-01
श्रृंखला:	Frontiers in Molecular Neuroscience
विषय:	amyotrophic lateral sclerosis (ALS) TDP-43 mitotoxicity liquid-liquid phase separation (LLPS) endocytosis frontotemporal lobar degeneration (FTLD)
ऑनलाइन पहुंच:	https://www.frontiersin.org/article/10.3389/fnmol.2019.00025/full
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