Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters

The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elim...

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Autors principals:	Fabio Benedetti, Federico Berti, Lidia Fanfoni, Michele Garbo, Giorgia Regini, Fulvia Felluga
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2016-06-01
Col·lecció:	Molecules
Matèries:	chiral pool allylamines amino acids sulfones acylation
Accés en línia:	http://www.mdpi.com/1420-3049/21/6/805
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