mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells

Abstract The mechanism regulating cellular senescence of postmitotic muscle cells is still unknown. cGAS-STING innate immune signaling was found to mediate cellular senescence in various types of cells, including postmitotic neuron cells, which however has not been explored in postmitotic muscle cel...

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Bibliografiske detaljer

Principais autores:	Ying Li, Jie Cui, Lei Liu, William S. Hambright, Yutai Gan, Yajun Zhang, Shifeng Ren, Xianlin Yue, Liwei Shao, Yan Cui, Johnny Huard, Yanling Mu, Qingqiang Yao, Xiaodong Mu
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2024-07-01
Serier:	Cell Death and Disease
Online adgang:	https://doi.org/10.1038/s41419-024-06863-8
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