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Substance P Hinders Bile Acid-Induced Hepatocellular Injury by Modulating Oxidative Stress and Inflammation

Liver failure is an outcome of chronic liver disease caused by steatohepatitis and cholestatic injury. This study examined substance P (SP) effect on liver injury due to cholestatic stress caused by excessive bile acid (BA) accumulation. Chenodeoxycholic acid (CDCA) was added to HepG2 cells to induc...

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Principais autores: Dahyeon Lee, Jeong Seop Park, Doyoung Kim, Hyun Sook Hong
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
coleção:Antioxidants
Assuntos:
bile acid
hepatocyte
substance P
inflammation
sinusoidal endothelium
Acesso em linha:https://www.mdpi.com/2076-3921/11/5/920
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