Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death

Retinitis pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1−/− mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating protein shown to modulate actin cytoskeletal dynamic...

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Dettagli Bibliografici

Autori principali:	Andy Shao, Antonio Jacobo Lopez, JiaJia Chen, Addy Tham, Seanne Javier, Alejandra Quiroz, Sonia Frick, Edward M. Levine, K. C. Kent Lloyd, Brian C. Leonard, Christopher J. Murphy, Thomas M. Glaser, Ala Moshiri
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	The Company of Biologists 2022-07-01
Serie:	Disease Models & Mechanisms
Soggetti:	arap1 rpe phagocytosis retinitis pigmentosa
Accesso online:	http://dmm.biologists.org/content/15/7/dmm049343
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