Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

Summary: Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome 12p [i(12p)] with two additional copies of the short arm of chromosome 12. By mapping sem...

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Autors principals:	Keren Cheng, Yasunari Seita, Eoin C. Whelan, Ryo Yokomizo, Young Sun Hwang, Antonia Rotolo, Ian D. Krantz, Jill P. Ginsberg, Thomas F. Kolon, Priti Lal, Xunda Luo, Phillip M. Pierorazio, Rebecca L. Linn, Sandra Ryeom, Kotaro Sasaki
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-06-01
Col·lecció:	Cell Reports
Matèries:	CP: Developmental biology CP: Cancer
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S221112472400651X
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