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Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

Summary: Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome 12p [i(12p)] with two additional copies of the short arm of chromosome 12. By mapping sem...

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Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Keren Cheng, Yasunari Seita, Eoin C. Whelan, Ryo Yokomizo, Young Sun Hwang, Antonia Rotolo, Ian D. Krantz, Jill P. Ginsberg, Thomas F. Kolon, Priti Lal, Xunda Luo, Phillip M. Pierorazio, Rebecca L. Linn, Sandra Ryeom, Kotaro Sasaki
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2024-06-01
Rangatū:Cell Reports
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Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S221112472400651X
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