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Comparative Analysis of Next-Generation Sequencing and Immunohistochemistry in MSI/MMR Testing

Objective: Loss of mismatch repair (MMR) protein expression, assessed via immunohistochemistry (IHC), and microsatellite instability (MSI) status, determined through molecular methods, are two tumor-agnostic predictive biomarkers for immunotherapy eligibility. However, there remains no consensus on...

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Main Authors: Cisel AYDIN MERICOZ, Zeynep Secil SATILMIS, Fatma ESREFI, Gulsum CAYLAK, Burcu SAKA, Ayse ARMUTLU, Orhun Cig TASKIN, Ibrahim KULAC
Format: Artigo
Language:Inglês
Published: Federation of Turkish Pathology Societies 2025-09-01
Series:Türk Patoloji Dergisi
Subjects:
next-generation sequencing
microsatellite instability
microsatellite stable
mismatch repair
Online Access:https://turkjpath.org/pdf.php?id=2100
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