Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole

Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, and dissolution is the rate-limiting step in the ove...

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Principais autores:	Harsh Shah, Kushal Shah, Bhavin Gajera, Rutesh H. Dave, David R. Taft
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2023-03-01
Series:	Pharmaceutics
Assuntos:	PBPK modeling absorption modeling model transfer experiment Simcyp<sup>™</sup> parameter sensitivity precipitation kinetics
Acceso en liña:	https://www.mdpi.com/1999-4923/15/4/1040
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