Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media

Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance. Absorption is determined by the solubility and permeabi...

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Detalhes bibliográficos

Principais autores:	Miao Zhang, Bin Wu, Shudong Zhang, Lin Wang, Qin Hu, Dongyang Liu, Xijing Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-01-01
Colecção:	Pharmaceutics
Assuntos:	precipitate physicochemical properties biorelevant media permeability weakly basic insoluble drugs
Acesso em linha:	https://www.mdpi.com/1999-4923/14/2/330
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