Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease associated with cardiomyopathy. DMD cardiomyopathy is characterized by abnormal intracellular Ca2+ homeostasis and mitochondrial dysfunction. We used dystrophin and utrophin double-knockout (mdx:utrn–/–) mice in a sarcolipin (...

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Autores principales:	Satvik Mareedu, Nadezhda Fefelova, Cristi L. Galindo, Goutham Prakash, Risa Mukai, Junichi Sadoshima, Lai-Hua Xie, Gopal J. Babu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical investigation 2024-05-01
Colección:	JCI Insight
Materias:	Metabolism
Acceso en línea:	https://doi.org/10.1172/jci.insight.170185
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