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Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis

Abstract Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn −/− mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD. Interestingly, these mice are i...

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Bibliografiske detaljer
Principais autores: Hung-Chih Chen, Yu-Feng Chin, David J. Lundy, Chung-Tiang Liang, Ya-Hui Chi, Paolin Kuo, Patrick C. H. Hsieh
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2017-08-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-017-05993-8
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