Macrophage IL-1β-positive microvesicles exhibit thrombo-inflammatory properties and are detectable in patients with active juvenile idiopathic arthritis

ObjectiveIL-1β is a leaderless cytokine with poorly known secretory mechanisms that is barely detectable in serum of patients, including those with an IL-1β-mediated disease such as systemic juvenile idiopathic arthritis (sJIA). Leukocyte microvesicles (MVs) may be a mechanism of IL-1β secretion. Th...

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Principais autores:	Audrey Cambon, Charlotte Rebelle, Richard Bachelier, Laurent Arnaud, Stéphane Robert, Marie Lagarde, Romain Muller, Edwige Tellier, Yéter Kara, Aurélie Leroyer, Catherine Farnarier, Loris Vallier, Corinne Chareyre, Karine Retornaz, Anne-Laure Jurquet, Tu-Anh Tran, Romaric Lacroix, Françoise Dignat-George, Gilles Kaplanski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-11-01
coleção:	Frontiers in Immunology
Assuntos:	microvesicles IL-1β NLRP3-inflammasome tissue factor juvenile idiopathic arthritis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228122/full
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