Identification of heparin interaction sites on thrombin-activatable fibrinolysis inhibitor that modulate plasmin-mediated activation, thermal stability, and antifibrinolytic potential

Background: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen that provides a molecular link between coagulation and fibrinolysis. Studies have shown that the presence of glycosaminoglycans accelerates TAFI activation by plasmin and stabilizes activated TAFI (TAFIa). Objectives:...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Tanya T. Marar, Michael B. Boffa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-05-01
coleção:	Research and Practice in Thrombosis and Haemostasis
Assuntos:	carboxypeptidase B2 fibrinolysis glycosaminoglycans heparin kinetics mutagenesis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2475037924001481
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!