Cuproplasia and cuproptosis in hepatocellular carcinoma: mechanisms, relationship and potential role in tumor microenvironment and treatment

Abstract Background Hepatocellular carcinoma (HCC) is the main phenotype of liver cancer with a poor prognosis. Copper is vital in liver function, and HCC cells rely on it for growth and metastasis, leading to cuproplasia. Excessive copper can induce cell death, termed cuproptosis. Tumor microenviro...

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Главные авторы:	Ruoyu Zhang, Yunfei Tan, Ke Xu, Ning Huang, Jian Wang, Mei Liu, Liming Wang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-04-01
Серии:	Cancer Cell International
Предметы:	Copper Cuproplasia Cuproptosis Hepatocellular carcinoma Mechanism Tumor microenvironment
Online-ссылка:	https://doi.org/10.1186/s12935-025-03683-4
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