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Cuproplasia and cuproptosis in hepatocellular carcinoma: mechanisms, relationship and potential role in tumor microenvironment and treatment

Abstract Background Hepatocellular carcinoma (HCC) is the main phenotype of liver cancer with a poor prognosis. Copper is vital in liver function, and HCC cells rely on it for growth and metastasis, leading to cuproplasia. Excessive copper can induce cell death, termed cuproptosis. Tumor microenviro...

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Principais autores: Ruoyu Zhang, Yunfei Tan, Ke Xu, Ning Huang, Jian Wang, Mei Liu, Liming Wang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-04-01
coleção:Cancer Cell International
Assuntos:
Copper
Cuproplasia
Cuproptosis
Hepatocellular carcinoma
Mechanism
Tumor microenvironment
Acesso em linha:https://doi.org/10.1186/s12935-025-03683-4
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