Macrophage-Induced Pro-Fibrotic Gene Expression in Tubular Cells after Ischemia/Reperfusion Is Paralleled but Not Directly Mediated by C5a/C5aR1 Signaling

Ischemia/reperfusion (I/R) is inevitable during kidney transplantation and causes acute kidney injury (AKI), which affects immediate outcome and leads to chronic changes such as fibrotic remodeling of the graft. We investigated pro-fibrotic signaling after I/R, focusing on the complement component a...

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Auteurs principaux:	Erik Bleich, Eva Vonbrunn, Maike Büttner-Herold, Kerstin Amann, Christoph Daniel
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2024-08-01
Collection:	Life
Sujets:	complement C5a macrophage/tubular crosstalk fibrosis ischemia/reperfusion
Accès en ligne:	https://www.mdpi.com/2075-1729/14/8/1031
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