TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2

Abstract Background Premature ovarian insufficiency (POI) is a severe disorder leading to female infertility. Genetic mutations are important factors causing POI. TP63-truncating mutation has been reported to cause POI by increasing germ cell apoptosis, however what factors mediate this apoptosis re...

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Principais autores:	Yali Fan, Shuya Chen, Chunfang Chu, Xiaodan Yin, Jing Jin, Lingyan Zhang, Huihui Yan, Zheng Cao, Ruixia Liu, Mingwei Xin, Lin Li, Chenghong Yin
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-03-01
Series:	Journal of Ovarian Research
Assuntos:	Premature ovarian insufficiency TP63 CLCA2 Apoptosis Whole-exome sequencing
Acceso en liña:	https://doi.org/10.1186/s13048-024-01396-2
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