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From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis

A genome-wide screen of 16,471 RNAi triggers targeting SARS-CoV-2 genome by Sens.AI. identifies hyper-potent RNAi candidates against SARS-CoV-2 that are further validated in vitro and in vivo.

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Hlavní autoři: Ohad Yogev, Omer Weissbrod, Giorgia Battistoni, Dario Bressan, Adi Naamati, Ilaria Falciatori, Ahmet Can Berkyurek, Roni Rasnic, Rhys Izuagbe, Myra Hosmillo, Shaul Ilan, Iris Grossman, Lauren McCormick, Christopher Cole Honeycutt, Timothy Johnston, Matthew Gagne, Daniel C Douek, Ian Goodfellow, Gregory James Hannon, Yaniv Erlich
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2023-03-01
Edice:Communications Biology
On-line přístup:https://doi.org/10.1038/s42003-023-04589-5
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