BRCA1 alleviates inflammation, oxidative stress, and ovarian granulosa cell apoptosis by inhibiting endoplasmic reticulum stress, thereby ameliorating polycystic ovary syndrome

Abstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by metabolic imbalance, oxidative stress, and granulosa cell (GC) dysfunction. Given the established role of BRCA1 in maintaining genomic stability and regulating stress responses, its potential involvement in...

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Autores principales:	Xiaolan Huang, Shuyin Zhang, Danhong Liang, Lingling Qiu, Ruiyun Wu, Rong Wei, Xiaoqing Chen, Suzhen Huang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-01-01
Colección:	European Journal of Medical Research
Materias:	Polycystic ovary syndrome BRCA1 Endoplasmic reticulum stress Oxidative stress Inflammation
Acceso en línea:	https://doi.org/10.1186/s40001-025-03734-6
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