Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells
Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same subcellular loci. Given that γ-secretase is i...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI AG
2023-02-01
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| Schriftenreihe: | Sensors |
| Schlagworte: | |
| Online-Zugang: | https://www.mdpi.com/1424-8220/23/5/2651 |
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