Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy

Pt(IV) compounds are regarded as prodrugs of active Pt(II) drugs (i.e. cisplatin, carboplatin, and oxaliplatin) and burgeoned as the most ideal candidates to substitute Pt(II) anticancer drugs with severe side effects. Nanoparticle drug delivery systems have been widely introduced to deliver Pt(IV)...

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Hauptverfasser:	Yuanlei Fu, Ying Kong, Xiangping Li, Dongfang Cheng, Yuqian Hou, Yan Li, Tongfang Li, Yani Xiao, Qiuyan Zhang, Rong Rong
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2023-12-01
Schriftenreihe:	Drug Delivery
Schlagworte:	Platinum(IV) prodrug self-assembled nanoparticles pharmacokinetics antitumor efficacy oxaliplatin
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/10717544.2023.2171158
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