Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas.

Epithelial ovarian cancer (EOC) is thought to arise in part from the ovarian surface epithelium (OSE); however, the molecular events underlying this transformation are poorly understood. Germline mutations in the BRCA1 tumor suppressor gene result in a significantly increased risk of developing EOC...

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Principais autores:	Katherine V Clark-Knowles, Mary K Senterman, Olga Collins, Barbara C Vanderhyden
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science (PLoS) 2009-12-01
סדרה:	PLoS ONE
גישה מקוונת:	http://europepmc.org/articles/PMC2795167?pdf=render
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!