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Structural mechanism of proton conduction in otopetrin proton channel

Abstract The otopetrin (OTOP) proteins were recently characterized as extracellular proton-activated proton channels. Several recent OTOP channel structures demonstrated that the channels form a dimer with each subunit adopting a double-barrel architecture. However, the structural mechanisms underly...

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Autori principali: Ninghai Gan, Weizhong Zeng, Yan Han, Qingfeng Chen, Youxing Jiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-08-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-024-51803-x
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