Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

Abstract Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules. The natural compound nordihydroguaiaretic acid (NDGA) robustly increases lifespan in...

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Hauptverfasser:	Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie Andersen, Aimee W. Kao, Eric Verdin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2019-10-01
Schriftenreihe:	npj Aging and Mechanisms of Disease
Online-Zugang:	https://doi.org/10.1038/s41514-019-0037-7
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