ALDH2 rs671 Variant Lowers Blood Pressure Via the Endothelial HSPA5–PIEZO1–eNOS Pathway

Background The inactivating ALDH2 rs671 polymorphism, present in ≈8% of the global population and up to 30% to 50% of East Asian individuals, has been negatively associated with hypertension. However, the direct role of ALDH2 (aldehyde dehydrogenase 2) dysfunction in this association, as well as the...

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Päätekijät:	Huaqing Ye, Hongwei Yue, Shujian Wei, Kaiyi Wang, Kehui Yang, Han Du, Wentao Sang, Jialin Guo, Jingwen Wang, Yunyun Guo, Cheng Zhang, Sumei Cui, Feng Xu, Yuguo Chen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2026-01-01
Sarja:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Aiheet:	ALDH2 ALDH2 rs671 blood pressure HSPA5 PIEZO1
Linkit:	https://www.ahajournals.org/doi/10.1161/JAHA.124.040121
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