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PET imaging of mGluR5 in Alzheimer’s disease

Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized the positron emission tomography (PET) radiol...

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Principais autores: Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-01-01
Serier:Alzheimer’s Research & Therapy
Fag:
mGluR5
Glutamate receptor
Alzheimer’s disease
[18F]FPEB
PET
Online adgang:https://doi.org/10.1186/s13195-020-0582-0
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