Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance. This study aimed to identify the genetic mutations as...

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Bibliografiske detaljer

Principais autores:	Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2023-12-01
Serier:	Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Fag:	Minimal inhibitory concentration Isoniazid Multi-drug resistant tuberculosis inhA katG
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2405579423000438
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