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Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance

Background: High-dose isoniazid is recommended in the 9–12 months short-course regimen for multidrug-resistant tuberculosis with inhA mutation. However, there is insufficient evidence to support the assumption of genotypic-phenotypic concordance. This study aimed to identify the genetic mutations as...

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主要な著者: Senamile Lale Ngema, Navisha Dookie, Rubeshan Perumal, Louansha Nandlal, Nikita Naicker, Marothi Peter Letsoalo, Max O'Donnell, Azraa Khan, Nesri Padayatchi, Kogieleum Naidoo
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2023-12-01
シリーズ:Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
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オンライン・アクセス:http://www.sciencedirect.com/science/article/pii/S2405579423000438
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