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Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction

Summary: Irreversible fibrosis is a hallmark of myocardial infarction (MI) and heart failure. Extracellular matrix protein-1 (ECM-1) is up-regulated in these hearts, localized to fibrotic, inflammatory, and perivascular areas. ECM-1 originates predominantly from fibroblasts, macrophages, and pericyt...

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Ngā kaituhi matua: Sean A. Hardy, PhD, Laura Liesinger, MSc, Ralph Patrick, PhD, Maria Poettler, PhD, Lavinia Rech, MD, Juergen Gindlhuber, PhD, Nishani S. Mabotuwana, BBmedHons, DiyaaEldin Ashour, PhD, Verena Stangl, MD, Mark Bigland, PhD, Lucy A. Murtha, PhD, Malcolm R. Starkey, PhD, Daniel Scherr, MD, Philip M. Hansbro, PhD, Gerald Hoefler, MD, Gustavo Campos Ramos, PhD, Clement Cochain, PhD, Richard P. Harvey, PhD, Ruth Birner-Gruenberger, PhD, Andrew J. Boyle, PhD, Peter P. Rainer, MD, PhD
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2023-12-01
Rangatū:JACC: Basic to Translational Science
Ngā marau:
extracellular matrix
fibroblasts
fibrosis
heart
inflammation
myocardial infarction
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2452302X23002310
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