Structure guided studies of the interaction between PTP1B and JAK
Abstract Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates. Here we identify PTP1B as an inhibitor of IL-6 a...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2023-06-01
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| coleção: | Communications Biology |
| Acesso em linha: | https://doi.org/10.1038/s42003-023-05020-9 |
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