Multiparameter antigen-specific immunoprofiling in subjects with negative IGRA and TST results with potential M. tuberculosis exposures

IntroductionAsymptomatic individuals with negative Interferon-γ release assay (IGRA) and tuberculin skin test (TST) results are often labeled as tuberculosis-unexposed individuals. We hypothesize that flow cytometric (FC) detection of antigen-stimulated T-cells in peripheral blood can differentiate...

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Egile Nagusiak:	Balaji Pathakumari, Luis E. Gutierrez, Shaji Ahmed Faisal, Pedro Arias Sanchez, Kale Daniel, Virginia P. Van Keulen, Heather R. Hilgart, Manik R. Reddy, Elitza Theel, Rafael Laniado-Laborin, Jeremy M. Clain, Tobias Peikert, Ryan C. Bailey, Patricio Escalante
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2026-05-01
Saila:	Frontiers in Cellular and Infection Microbiology
Gaiak:	latent tuberculosis infection tuberculosis exposure flow cytometry TST/IGRA T cell markers
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fcimb.2026.1837269/full
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