A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure

Abstract Background Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals—so-called resisters—have persistently negative results for the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs). “Resistance to immune conversion” is the best-known clinical cor...

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Prif Awduron:	Clément Conil, Jonathan Bohlen, Elouise E. Kroon, Marc. A. Jean-Juste, Jérémy Manry, Matthieu Chaldebas, James M. Bean, Kathleen F. Walsh, Monica Dallmann-Sauer, Maxime Rotival, Yoann Seeleuthner, Astrid Marchal, Haralambos Mourelatos, Vinicius M. Fava, Peng Zhang, Gaspard Kerner, Hanaa Skhoun, Ahmed Abid, Hanane El Ouazzani, Aniss Rafik, Ahmed Aziz Bousfiha, Jamila El Baghdadi, Robert J. Wilkinson, Stéphanie Boisson-Dupuis, Daniel W. Fitzgerald, Jean W. Pape, Marlo Möller, Eileen G. Hoal, Jean-Laurent Casanova, Laurent Abel, Erwin Schurr, Aurélie Cobat
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-10-01
Cyfres:	Genome Medicine
Pynciau:	Whole genome sequencing Genome-wide association study Regulatory variants Mycobacterium tuberculosis TST IGRA
Mynediad Ar-lein:	https://doi.org/10.1186/s13073-025-01547-0
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