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Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation

Abstract The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer’s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were upregulated in response to tau accumulation. To fur...

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Principais autores: Aleksandra M. Wojtas, Yari Carlomagno, Jonathon P. Sens, Silvia S. Kang, Tanner D. Jensen, Aishe Kurti, Kelsey E. Baker, Taylor J. Berry, Virginia R. Phillips, Monica Casey Castanedes, Ayesha Awan, Michael DeTure, Cristhoper H. Fernandez De Castro, Ariston L. Librero, Mei Yue, Lillian Daughrity, Karen R. Jansen-West, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, John D. Fryer
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-12-01
coleção:Acta Neuropathologica Communications
Assuntos:
Clusterin
Alzheimer’s disease
Tauopathy
Tau
Acesso em linha:https://doi.org/10.1186/s40478-020-01079-1
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