BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Abstract Background Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1, which is required for Aβ generation, is therefore being explored for the treatment of AD by reducing Aβ accumulation. As Ba...

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Detalhes bibliográficos

Principais autores:	John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu, Riqiang Yan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-05-01
coleção:	Molecular Neurodegeneration
Assuntos:	BACE1 Amyloid plaques Reactive astrocytes Clusterin CXCL14 Insulin receptor
Acesso em linha:	https://doi.org/10.1186/s13024-023-00611-w
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