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Prognosis and risk factors for pathological non-response to neoadjuvant chemoimmunotherapy in locally advanced esophageal squamous cell carcinoma

BackgroundNeoadjuvant chemotherapy combined with immunotherapy (NACI) is promising for treating locally advanced esophageal squamous cell carcinoma (LA-ESCC), yet a subset of patients exhibit a pathological non-response (pNR). The prognosis and risk factors for pNR to NACI remain unclear.MethodsWe r...

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Principais autores: Jun-Peng Lin, Hui Lin, Hao He, Feng-Nian Zhuang, Wei-Jie Chen, Yu-Jie Chen, Peiyuan Wang, Hang Zhou, Wen-Wei Wei, Peng-Qiang Gao, Shuo-Yan Liu, Feng Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-04-01
Serier:Frontiers in Immunology
Fag:
esophageal squamous cell carcinoma
neoadjuvant immunotherapy
pathological non-response
prognosis
risk factors
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1815244/full
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