Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer

BackgroundRecurrence risk in breast cancer remains heterogeneous, and conventional clinicopathological variables may not fully capture the contribution of immune-related factors. We compared multiple survival modeling strategies and evaluated whether an integrated immune-inflammatory phenotype could...

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Główni autorzy:	Shanshan Han, Lin Ran, Zhaoan Lian, Yong Tian, Li Qin, Yingchun Xiang, Xiaohao Yan, Chengyu Shui, Cheng Huang
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2026-06-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	breast cancer disease-free survival integrated immune phenotype random survival forest systemic immune-inflammation index tumor-infiltrating lymphocytes
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1836156/full
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