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Obtusifolin ameliorates dry eye model in rats by reducing inflammation and blocking MAPK/NF-κB pathways

AIM: To investigate the functions and potential mechanisms of obtusifolin in dry eye disease (DED) in a rat model. METHODS: A rat DED model was established via topical administration of benzalkonium chloride (BAC), followed by administration of obtusifolin. Conjunctival irritation score and tear pro...

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Autori principali: Dan Zhu, Xiao-Yang Wu, Liang-Chang Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Press of International Journal of Ophthalmology (IJO PRESS) 2025-08-01
Serie:International Journal of Ophthalmology
Soggetti:
dry eye disease
obtusifolin
inflammation
tear production
mitogen-activated protein kinase/nuclear factor kappa b
rats
Accesso online:http://ies.ijo.cn/en_publish/2025/8/20250802.pdf
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