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191Pt-labeled trithiol-Hoechst-PSMA: preliminary evaluation of conjugates designed for delivery to genomic DNA of PSMA-positive cancers

Abstract Background Several platinum radionuclides, including 191Pt, are promising candidates for DNA-targeted Auger electron radiotherapy; however, effective compound designs are needed for this application. In this study, we developed six novel 191Pt-labeled compounds and evaluated their DNA-targe...

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Kaydedildi:
Asıl Yazarlar: Honoka Obata, Atsushi B. Tsuji, Yutian Feng, Yongxiang Zheng, Aya Sugyo, Hitomi Sudo, Chie Kajiwara, Katsuyuki Minegishi, Ming-Rong Zhang, Michael R. Zalutsky
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: SpringerOpen 2026-01-01
Seri Bilgileri:EJNMMI Radiopharmacy and Chemistry
Konular:
Platinum-191
Auger electrons
Trithiol
PSMA
Biodistribution
Tumor DNA binding
Online Erişim:https://doi.org/10.1186/s41181-025-00420-0
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