The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ∼40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent...

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Principais autores:	Sian E Evans, Benjamin T Goult, Louise Fairall, Andrew G Jamieson, Paul Ko Ferrigno, Robert Ford, John W R Schwabe, Simon D Wagner
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2014-01-01
叢編:	PLoS ONE
在線閱讀:	https://doi.org/10.1371/journal.pone.0090889
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