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The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction

Pyroptosis is an inflammatory form of cell death involving caspase-1 or caspase-4/5/11, initiated by inflammasomes or cytoplasmic endotoxins as part of the immune defense. It is specifically characterized by Gasdermin-mediated pore formation leading to cell lysis, pyroptosis also entails the release...

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Auteurs principaux: Lujian Zhu, Minli Hu, Haoming Xu, Hanglu Xu, Binbin Ren, Ruiyan Xu, Maodong Guo, Haijun Chen, Dehe Zhang, Hao Fang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2025-05-01
Collection:Frontiers in Pharmacology
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Accès en ligne:https://www.frontiersin.org/articles/10.3389/fphar.2025.1586364/full
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