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PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis

Abstract Background Liver fibrosis is a progressive disorder resulting from chronic liver injury, and its molecular mechanism remains incompletely elucidated. Methods The role of PROM2 was assessed by integrating transcriptomic datasets with in vivo liver fibrosis models. Functional analyses were pe...

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Príomhchruthaitheoirí: Jiashi Guo, Yan Lin, Xia Gong, Ge Kuang, Jun Hu, Hui Du, Hao Liu, Jiao Zhang, Li Zhang, Jingyuan Wan, Ting Wang
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Springer 2025-11-01
Sraith:Cellular and Molecular Life Sciences
Ábhair:
Rochtain ar líne:https://doi.org/10.1007/s00018-025-05920-5
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