Recruitment of transcriptional effectors by Cas9 creates cis-regulatory elements and demonstrates distance-dependent transcriptional regulation

Summary: Regulation of cardiac gene expression, especially for sarcomeric genes, is crucial for heart function and is often mediated by distal regulatory elements such as enhancers and repressors. Despite their importance, the link between transcription factor recruitment to distant genomic regions...

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Detalhes bibliográficos

Principais autores:	Jubran Boulos, Arkadiy K. Golov, Nadav Keren, Itai Erlich, Nardeen Shehadeh, Nili Avidan, Hagai Kariti, Omer Sadeh, Lilac Haimovich-Caspi, Adam Helms, Noam Kaplan, Izhak Kehat
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
Colecção:	iScience
Assuntos:	gene network molecular mechanism of gene regulation genomic analysis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004225023016
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