USP22 suppresses trophoblast cell necroptosis in preeclampsia by stabilizing KAT2A-mediated histone acetylation at the SFRP1 promoter
Abstract Background Preeclampsia (PE) is a severe gestational disorder associated with impaired placental function. Necroptosis contributes substantially to trophoblast injury in PE, though the upstream epigenetic regulatory pathways are not yet fully elucidated. This study investigated how the deub...
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| Principais autores: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BMC
2026-06-01
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| 叢編: | Journal of Translational Medicine |
| 主題: | |
| 在線閱讀: | https://doi.org/10.1186/s12967-026-08513-3 |
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