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TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia

Impaired invasion of EVTs results in inadequate remodelling of arteries and poor placentation, leading to PE. TMBIM4 was found to promote the migration and invasion of human osteosarcoma U2-OS and breast cancer MCF7 cell lines. However, the effect of TMBIM4 on trophoblast biological behaviour and it...

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Principais autores: Yuanyao Chen, Lin Xiao, Guoqiang Sun, Min Li, Hailan Yang, Zhangyin Ming, Kai Zhao, Xuejun Shang, Huiping Zhang, Chunyan Liu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-01-01
coleção:Biology
Assuntos:
TMBIM4
pyroptosis
NLRP3 inflammasome
preeclampsia
trophoblasts
Acesso em linha:https://www.mdpi.com/2079-7737/12/2/208
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