Reciprocal activation between M1 macrophages and trophoblasts through CXCL9/STAT1/ZEB1/CCL2 axis promotes recurrent spontaneous abortion

BackgroundThe crosstalk between macrophages and trophoblasts plays a crucial role in the development and progression of recurrent spontaneous abortion (RSA). Although M1 macrophages (M1-Mφ) are known to accumulate in RSA decidual tissues, their direct functional impact on trophoblasts remains poorly...

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Hlavní autoři:	Sisi Yan, Xiang Wang, Qiuji Wu, Jinli Ding, Hui Qiu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Immunology
Témata:	recurrent spontaneous abortion M1-Mφ trophoblasts CXCL9 migration and invasion EMT
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1629370/full
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